Fluorenones are important constituents in material, medical and chemical sciences with potential applications in various domains. The key factors responsible for the diverse usage of fluorenones in material sciences are their intriguing and tunable photo, as well as their physicochemical properties. Besides this, the presence of conjugated poly-(en)ynes in the fluorenones makes the molecules of interest in material sciences. Fluorenones show various biological activities like antibiotics, anticancer, antiviral, and neuromodulatory, etc. Organic chemists are developing various protocols for the synthesis of fluorenones. Despite several protocols developed for their synthesis since 1931, there is no review covering their entire synthetic protocols. This review includes several classical and novel synthetic approaches for the synthesis of fluorenones. Furthermore, we delineated the mechanism by which they have been synthesized.
Structure of Fluorenone
Tom's professor gets things kicked off by introducing the class to the structure of fluorenone. Fluorenone is an aromatic compound that contains a five-membered ring with a carbonyl group attached and two benzene rings fused on either side. Let's break that down a bit.
'Aromatic' means that
the compound contains an alternating network of double and single bonds all the
way around each benzene ring. Notice that the five-membered ring that looks
like a pentagon is sandwiched right in the middle of each benzene ring. These
types of ring systems are joined together which are called fused ring
systems. We could say that the five-membered ring has a benzene ring 'fused' to
each side of it.
A carbonyl group in
organic chemistry is always defined as a carbon-oxygen double bond. If the
carbonyl group is bonded to two other carbon atoms (as with fluorenone) then that particular functional group is known as a ketone.
Product Packaging
25kgs/drum
Product Storage
Please store in a dry,
cool, and dark place.
Solubility of
Fluorenone
The next thing Tom's
professor discusses is the solubility of fluorenone. When we talk about the solubility
of a compound, we refer to whether or not it will form a solution with a given
solvent, in other words, will it dissolve. If it does, we say that the compound
is soluble. If it doesn't, it is insoluble.
Fluorenone is soluble
in a wide range of organic solvents (solvents that are carbon-hydrogen based)
including things like chloroform, methanol, ethanol, dichloromethane, and
acetonitrile.
An important thing to
realize, however, is that fluorenone is NOT soluble in water. This is actually
the case for a lot of organic compounds. The reason will become more apparent
when we talk about its polarity in the next section.
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